Research Education

Welcome to the Omni-Biotic® Research and Education resource center. Here you will find a variety of reviews, meta analyses, and clinical studies. Where a specific probiotic formulation is studied, it is most often referred to with the European brand name, but the formulations we offer in the United States are identical to the original.

Gut-Brain Axis and Omni-Biotic Stress Release Publications

The PROVIT Study-Effects of Multi-species Probiotic Add-on Treatment on Metabolomics in Major Depressive Disorder-A Randomized, Placebo-Controlled Trial.
Author/Year: Kreuzer et al; 2022
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
Shift toward significantly higher levels of:
  • Butyrate
  • Alanine
  • Valine
  • Isoleucine
  • Sarcosine
  • Methylamine
  • Lysine
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Effects of Probiotic Strains on Disease Activity and Enteric Permeability in Psoriatic Arthritis–A Pilot Open-Label Study
Author/Year: Haidmayer et al., 2020
Study Type: Pilot Study
Key findings include:
  • Reduction in psoriatic arthritis disease activity
  • Reduced in fecal zonulin (marker of intestinal permeability)
  • Reduced fecal calprotectin (marker of intestinal inflammation)
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"Influence of 4-week multi-strain probiotic administration on resting state functional connectivity in healthy volunteers"
Author/Year: Bagga, et al.; 2019
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Decreased functional connectivity in default mode, middle and superior frontal gyrus networks
  • Increased functional connectivity in salience network (cingulate gyrus and precuneus cortex)
  • Brain activity shift indicative of less connectivity associated with ruminative thought and more connectivity associated with executive function
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The Impact of Probiotic Supplements on Cognitive Parameters in Euthymic Individuals with Bipolar Disorder: A Pilot Study.
Author/Year: Reininghaus et al; 2018
Study Type: Pilot Study
Key findings include:
Significant improvements in:
  • Attention
  • Psychomotor processing speed
  • Executive function
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Probiotics drive gut microbiome triggering emotional brain signatures
Author/Year: Bagga, et al.; 2018
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Improved positive affect and cognitive reactivity
  • Improved memory performance
  • Improved gut microbiome diversity
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Effects of an oral symbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome
Author/Year: Moser et al., 2018
Study Type: Observational Study
Key findings include:
  • 80% reduction in IBS symptom severity
  • 46% reduction in zonulin (leaky gut marker)
  • Anti-inflammatory effects in the colon
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Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study
Author/Year: Leblhuber et al., 2018
Study Type: Observational Study
Key findings include:
  • Significant improvement in zonulin levels (gut barrier integrity)
  • Increase in the anti-inflammatory Faecalibacterium prausnitzii
  • Increased levels of neuroprotective kynurenine
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Gut-Liver Axis and Omni-Biotic Hetox Publications

Effects of a synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study.
Author/Year: Horvath et al; 2019
Study Type: Pilot Study
Key findings include:
Improvements in:
  • Hip circumference
  • Zonulin levels
  • Lipoprotein(a)
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Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial
Author/Year: Sabico et al., 2018
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Reduced circulating endotoxin levels (70%)
  • Reduced metabolic markers: glucose (38%), insulin (38%), HOMA-IR (64%), triglycerides (48%), total cholesterol (19%), total/HDL-cholesterol ratio (19%)
  • Reduced inflammatory markers: TNF-α (67%), IL-6 (77%), CRP (53%), resistin (53%)
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Dose-Dependent Effects of Multispecies Probiotic Supplementation on the Lipopolysaccharide (LPS) Level and Cardiometabolic Profile in Obese Postmenopausal Women: A 12-Week Randomized Clinical Trial
Author/Year: Szulinska et al., 2018
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
Improvements in:
  • Improvements in lipopolysaccharide levels
  • Reduced waist circumference and fat mass/subcutaneous fat
  • Improvements in total cholesterol, triglycerides, and low-density lipoprotein
  • Improved glucose and HOMA-IR levels
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Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial
Author/Year: Sabico et al., 2017
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Reduced abdominal adiposity (hip:waist ratio)
  • Improved HOMA-IR
  • Demonstrated safety and efficacy in medication naive T2DM
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Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis
Author/Year: Horvarth et al., 2016
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Increased neutrophil resting burst and neopterin levels
  • Improvement in liver function
  • Demonstrated safety and efficacy in stable liver cirrhosis
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The effects of the probiotic mixture on migraine: results of an open-label pilot study.
Author/Year: de Roos et al; 2015
Study Type: Pilot Study
Key findings include:
Improvements in:
  • Migraine intensity
  • Migraine frequency
  • Migraine Disability Assessment Scale (MIDAS)
Read full study

Gut-Immunity/GALT and Omni-Biotic Balance Publications

Influencing Secretory IgA Deficiencies in Sports Students through Nutritional Supplements
Author/Year: K. Jung, et al, 1999
Study Type: Master’s Thesis
Key findings include:
  • 75% improvement in sIgA levels after 4 weeks of taking Omni-Biotic Balance
  • Normalization of sIgA value in 44% of participants
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An Indication-Specific Multi-Species Probiotic Reduces Skin Problems and Significantly Reduces Allergy Symptoms and Susceptibility to Infections
Author/Year: Kolleritsch & Auinger, 2025
Study Type: Observational study, 1,400 participants
Key findings include:
  • 83% improvement in skin complaints after 8 weeks
  • 81% improvement in symptoms of atopic dermatitis
  • 84% improvement in Urticaria symptoms
  • 87% reduction in allergy complaints such as runny nose and itchy eyes
  • 87% reduction in GI complaints
Identification of Strong Interleukin-10 Inducing Lactic Acid Bacteria Which Downregulate T Helper Type 2 Cytokines
Author/Year: Niers et al; 2005
Study Type: Preclinical
Key findings include:
  • Omni-Biotic Balance probiotic strains strongly induced IL-10 production (immune tolerance)
  • Omni-Biotic Balance strains downregulate Th2 cytokines e.g., IL-4, IL-5, IL-13 (allergic response)
  • Omni-Biotic Balance strains shift immune balance toward regulatory/Treg responses
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Gut Restoration and Omni-Biotic AB 10 Publications

Effect of a Multispecies Probiotic on Intestinal and Skin Colonization by Multidrug Resistant Gram Negative Bacteria in Patients in a Long Term Care Facility
Author/Year: Zollner-Schwetz et al., 2020
Study Type: Pilot Study
Key findings include:
  • 58% reduction in multidrug resistant gram negative infection (stool)
  • 72% reduction in multidrug resistant gram negative infection (skin)
  • Demonstrated safety and efficacy in long term care facilities
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Probiotics Use for Antibiotic Associated Diarrhea: A Pragmatic Participatory Evaluation in Nursing Homes
Author/Year: Wietmarschen et al., 2020
Study Type: Participatory Evaluation
Key findings include:
  • 16% reduction in antibiotic associated diarrhea episodes
  • Demonstrated safety and efficacy in nursing homes
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Dysbiosis in Early Sepsis can be Modulated by a Multispecies Probiotic: a Randomised Controlled Pilot Trial.
Author/Year: Stadlbauer V, et al; 2019
Study Type: Pilot Study
Key findings include:
  • Validation of probiotic colonization
  • Improved functional microbiota diversity
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Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic
Author/Year: Hell et al., 2013
Study Type: Retrospective Chart Review
Key findings include:
  • Complete resolution of recurrent C. diff infection
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Use of a multi-species probiotic for the prevention of antibiotic associated diarrhea
Author/Year: Lang, 2010
Study Type: Observational Study
Key findings include:
  • Significant reduction in antibiotic associated diarrhea
  • Reduction in overall healthcare costs
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The effect of a multispecies probiotic on the intestinal microbiota and bowel movements in healthy volunteers taking the antibiotic amoxycillin.
Author/Year: Konig, et al; 2008
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Significant reduction in diarrhea-like bowel movements
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Probiotic Therapy of Gastrointestinal Symptoms During COVID-19
Author/Year: Horvath et al; 2024
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Omni-Biotic AB 10 significantly modulated gut microbiome composition and diversity in COVID-19 patients
  • Results demonstrated E. faecium colonization
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Probiotic OMNi-BiOTiC® 10 AAD Reduces Cyclophosphamide-Induced Inflammation and Adipose Tissue Wasting in Mice
Author/Year: Obermüller et al; 2023
Study Type: Preclinical
Key findings include:
  • Omni-Biotic AB 10 ameliorated body weight loss and preserved adipose tissue
  • Intervention reduced intestinal permeability
  • Intervention reduced colonic inflammation and goblet cell loss
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Insights into the Composition of a Co-Culture of 10 Probiotic Strains (OMNi-BiOTiC® AAD10) and Effects of Its Postbiotic Culture Supernatant
Author/Year: Kienesberger et al., 2022
Study Type: Preclinical
Key findings include:
  • Omni-Biotic AB 10 postbiotic supernatant demonstrated antibacterial and antifungal activity in vitro
  • Omni-Biotic 10 promoted growth of beneficial taxa (e.g., Faecalibacterium prausnitzii)
  • Multi-strain co-culture showed dynamic shifts in bacterial abundance and metabolite production
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Microbiome | Immune Development and Omni-Biotic PandA Publications

The Effects of Selected Probiotic Strains on the Development of Eczema (the PandA study)
Author/Year: 2009; Niers, et al
Publication Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Significantly lower incidence of infant eczema
  • Decreased IL-5 production
  • Increased Lc. lactis colonization
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Probiotic Supplementation Influences Faecal Short Chain Fatty Acids in Infants at High Rick for Eczema
Author/Year: Kim, et al.; 2015
Study Type: Randomized Controlled Trial (RCT)-follow on
Key findings include:
  • Increased short chain fatty acid and lactate production
  • Decreased lactose and succinate levels
  • Demonstrated safety and efficacy in children at risk to develop eczema
Read full study

Gut Modulated Athletic Performance and Omni-Biotic Power Publications

Probiotic Supplements Beneficially Affect Tryptophan-Kynurenine Metabolism and Reduce the Incidence of Upper Respiratory Tract Infections in Trained Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial.
Author/Year: Strasser, et al; 2016
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Reduced exercise induced tryptophan degradation
  • Decreased upper respiratory tract infections
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Probiotic Supplementation affects Markers of Intestinal Barrier, Oxidation, and Inflammation in Trained Men; a randomized, double-blinded, placebo-controlled trial.
Author/Year: Lamprecht, et al; 2012
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
Significant improvements in:
  • Zonulin levels
  • Carbonyl proteins (oxidative stress marker)
  • TNF-α
Read full study