Gut Restoration and Omni-Biotic AB 10 Publications

Diagram showing gut microbiome disruption, with sections for diverse/stable microbiota, reduced microbial diversity, and undesirable organism overgrowth

Undesirable microorganisms can easily disrupt the function and balance of the gut microbiome. Whether from changes in medications, environment, diet, or other factors, friendly, resident gut bacteria often need support and a quality probiotic can help.

Clinical studies have demonstrated the restorative power of OMNi-BiOTiC® AB 10 with outcomes including a significant reduction in AAD, improvement in digestive health and comfort, as well as complete resolution of CDI.

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Human Clinical Trials on Final Omni-Biotic Formulation

The following studies were performed on the commercial Omni-Biotic formulation available in the US market. In some cases the brand name will differ based on the European marketed product, but probiotic strains and formulation are identical.

Effect of a Multispecies Probiotic on Intestinal and Skin Colonization by Multidrug Resistant Gram Negative Bacteria in Patients in a Long Term Care Facility
Author/Year: Zollner-Schwetz et al., 2020
Study Type: Pilot Study
Key findings include:
  • 58% reduction in multidrug resistant gram negative infection (stool)
  • 72% reduction in multidrug resistant gram negative infection (skin)
  • Demonstrated safety and efficacy in long term care facilities
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Probiotics Use for Antibiotic Associated Diarrhea: A Pragmatic Participatory Evaluation in Nursing Homes
Author/Year: Wietmarschen et al., 2020
Study Type: Participatory Evaluation
Key findings include:
  • 16% reduction in antibiotic associated diarrhea episodes
  • Demonstrated safety and efficacy in nursing homes
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Dysbiosis in Early Sepsis can be Modulated by a Multispecies Probiotic: a Randomised Controlled Pilot Trial.
Author/Year: Stadlbauer V, et al; 2019
Study Type: Pilot Study
Key findings include:
  • Validation of probiotic colonization
  • Improved functional microbiota diversity
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Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic
Author/Year: Hell et al., 2013
Study Type: Retrospective Chart Review
Key findings include:
  • Complete resolution of recurrent C. diff infection
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Use of a multi-species probiotic for the prevention of antibiotic associated diarrhea
Author/Year: Lang, 2010
Study Type: Observational Study
Key findings include:
  • Significant reduction in antibiotic associated diarrhea
  • Reduction in overall healthcare costs
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The effect of a multispecies probiotic on the intestinal microbiota and bowel movements in healthy volunteers taking the antibiotic amoxycillin.
Author/Year: Konig, et al; 2008
Study Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Significant reduction in diarrhea-like bowel movements
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Preclinical Trials

The following studies were performed on either the constituent ingredients or the final Omni-Biotic formulation available in the US market.

Insights into the Composition of a Co-Culture of 10 Probiotic Strains (Omni-Biotic AB 10) and Effects of Its Postbiotic Culture Supernatant
Author/Year: Kienesberger, et al; 2022
Study Type: Preclinical
Key findings:
  • Anti-bacterial effect
  • Anti-fungal effect
  • Distinct commensal bacterial growth
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Reviews

The following papers are not specific to Omni-Biotic products but are provided here for informational and educational purposes.

Probiotics for the Prevention of Antibiotic-associated Diarrhea and Clostridium difficile Infection among Hospitalized Patients: systematic review and meta-analysis
Year Published: 2013
Study Type: Review

This systematic review and meta-analysis evaluated the efficacy of co-administration of probiotics with antibiotics. Findings demonstrated that probiotics used concurrently with antibiotics reduce the risk of antibiotic associated diarrhea and C. difficile infection.
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