Clinical Studies

Omni-Biotic AB 10

CLINICAL STUDY #1

"Insights into the Composition of a Co-Culture of 10 Probiotic Strains (OMNi BiOTiC® AAD10) and Effects of Its Postbiotic Culture Supernatant"

Published: 2020

Study Type: Preclinical
Related Omni-Biotic Formulation: AB 10

  • Antifungal Activity
  • Antibacterial Activity
  • Gut Microbiome Supportive
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CLINICAL STUDY #2

"Effect of a Multispecies Probiotic on Intestinal and Skin Colonization by Multidrug Resistant Gram Negative Bacteria in Patients in a Long Term Care Facility"

Published: 2020

Study Type: pilot study
Related Omni-Biotic Formulation: AB 10

  • <58% reduction in multidrug resistant gram negative infection (stool)
  • <72% reduction in multidrug resistant gram negative infection (skin)
  • Demonstrated safety and efficacy in long term care facilities
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CLINICAL STUDY #3

"Probiotics Use for Antibiotic Associated Diarrhea: A Pragmatic Participatory Evalution in Nursing Homes"

Published: 2020

Study Type: participatory evaluation
Related Omni-Biotic Formulation: AB 10

  • 16% reduction in antibiotic associated diarrhea
  • Demonstrated safety and efficacy in nursing homes
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CLINICAL STUDY #4

"Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic"

Published: 2013

Study Type: pilot study
Related Omni-Biotic Formulation: AB 10

  • Complete resolution of Clostridium difficile infection
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CLINICAL STUDY #5

"Use of a multi-species probiotic for the prevention of antibiotic associated diarrhea"

Published: 2010

Study Type: observational study
Related Omni-Biotic Formulation: AB 10

This observational study demonstrated the successful use of Omni-Biotic AB 10 (AAD) for primary prevention of antibiotic associated diarrhea in post surgical patients.

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CLINICAL STUDY #6

"Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta-analysis"

Published: 2013

Study Type: review article
Related Omni-Biotic Formulation: AB 10

This systematic review and meta-analysis evaluated the efficacy of co-administration of probiotics with antibiotics. Findings demonstrated that probiotics used concurrently with antibiotics reduce the risk of antibiotic associated diarrhea and C. difficile infection.

Read full study

CLINICAL STUDY #1

"Insights into the Composition of a Co-Culture of 10 Probiotic Strains (OMNi BiOTiC® AAD10) and Effects of Its Postbiotic Culture Supernatant"

Published: 2020

Study Type: Preclinical
Related Omni-Biotic Formulation: AB 10

  • Antifungal Activity
  • Antibacterial Activity
  • Gut Microbiome Supportive
Read full study

CLINICAL STUDY #2

"Effect of a Multispecies Probiotic on Intestinal and Skin Colonization by Multidrug Resistant Gram Negative Bacteria in Patients in a Long Term Care Facility"

Published: 2020

Study Type: pilot study
Related Omni-Biotic Formulation: AB 10

  • <58% reduction in multidrug resistant gram negative infection (stool)
  • <72% reduction in multidrug resistant gram negative infection (skin)
  • Demonstrated safety and efficacy in long term care facilities
Read full study

CLINICAL STUDY #3

"Probiotics Use for Antibiotic Associated Diarrhea: A Pragmatic Participatory Evalution in Nursing Homes"

Published: 2020

Study Type: participatory evaluation
Related Omni-Biotic Formulation: AB 10

  • 16% reduction in antibiotic associated diarrhea
  • Demonstrated safety and efficacy in nursing homes
Read full study

CLINICAL STUDY #4

"Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic"

Published: 2013

Study Type: pilot study
Related Omni-Biotic Formulation: AB 10

  • Complete resolution of Clostridium difficile infection
Read full study

CLINICAL STUDY #5

"Use of a multi-species probiotic for the prevention of antibiotic associated diarrhea"

Published: 2010

Study Type: observational study
Related Omni-Biotic Formulation: AB 10

This observational study demonstrated the successful use of Omni-Biotic AB 10 (AAD) for primary prevention of antibiotic associated diarrhea in post surgical patients.

Read full study

CLINICAL STUDY #6

"Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta-analysis"

Published: 2013

Study Type: review article
Related Omni-Biotic Formulation: AB 10

This systematic review and meta-analysis evaluated the efficacy of co-administration of probiotics with antibiotics. Findings demonstrated that probiotics used concurrently with antibiotics reduce the risk of antibiotic associated diarrhea and C. difficile infection.

Read full study

Omni-Biotic Stress Release

CLINICAL STUDY #1

"Effects of Probiotic Strains on Disease Activity and Enteric Permeability in Psoriatic Arthritis–A Pilot Open-Label Study"

Published: 2020

Study Type: pilot clinical
Related Omni-Biotic Formulation: Stress Release

  • Reduction in psoriatic arthritis disease activity
  • Reduced in fecal zonulin (marker of intestinal permeability)
  • Reduced fecal calprotectin (marker of intestinal inflammation)
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CLINICAL STUDY #2

"Influence of 4-week multi-strain probiotic administration on resting state functional connectivity in healthy volunteers"

Published: 2019

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Stress Release

  • Decreased functional connectivity in default mode, middle and superior frontal gyrus networks
  • Increased functional connectivity in salience network (cingulate gyrus and precuneus cortex)
  • Brain activity shift indicative of less connectivity associated with ruminative thought and more connectivity associated with executive function
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CLINICAL STUDY #3

"Probiotics drive gut microbiome triggering emotional brain signatures"

Published: 2018

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Stress Release

  • Improved positive affect and cognitive reactivity
  • Improved memory performance
  • Improved gut microbiome diversity
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CLINICAL STUDY #4

"Effects of an oral synbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome"

Published: 2019

Study Type: observational trial
Related Omni-Biotic Formulation: Stress Release

  • Increased gut microbiome diversity and short chain fatty acid production
  • Reduced inflammatory CD4+ T cells and fecal zonulin levels
  • Decreased IBS disease severity
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CLINICAL STUDY #5

"The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems"

Published: 2015

Study Type: review article
Related Omni-Biotic Formulation: Stress Release

This review summarizes the available evidence describing the bi-directional gut-brain relationship including neural, endocrine, immune, and humoral pathways. It also explores relevant pathophysiological mechanisms.

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CLINICAL STUDY #6

"Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome"

Published: 2015

Study Type: review article
Related Omni-Biotic Formulation: Stress Release

This review highlights the evidence supporting the connection between stress and the gut microbiota, with specific focus on the mechanisms by which the microbiota impacts stress response, behavior, and visceral pain.

Read full study

CLINICAL STUDY #1

"Effects of Probiotic Strains on Disease Activity and Enteric Permeability in Psoriatic Arthritis–A Pilot Open-Label Study"

Published: 2020

Study Type: pilot clinical
Related Omni-Biotic Formulation: Stress Release

  • Reduction in psoriatic arthritis disease activity
  • Reduced in fecal zonulin (marker of intestinal permeability)
  • Reduced fecal calprotectin (marker of intestinal inflammation)
Read full study

CLINICAL STUDY #2

"Influence of 4-week multi-strain probiotic administration on resting state functional connectivity in healthy volunteers"

Published: 2019

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Stress Release

  • Decreased functional connectivity in default mode, middle and superior frontal gyrus networks
  • Increased functional connectivity in salience network (cingulate gyrus and precuneus cortex)
  • Brain activity shift indicative of less connectivity associated with ruminative thought and more connectivity associated with executive function
Read full study

CLINICAL STUDY #3

"Probiotics drive gut microbiome triggering emotional brain signatures"

Published: 2018

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Stress Release

  • Improved positive affect and cognitive reactivity
  • Improved memory performance
  • Improved gut microbiome diversity
Read full study

CLINICAL STUDY #4

"Effects of an oral synbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome"

Published: 2019

Study Type: observational trial
Related Omni-Biotic Formulation: Stress Release

  • Increased gut microbiome diversity and short chain fatty acid production
  • Reduced inflammatory CD4+ T cells and fecal zonulin levels
  • Decreased IBS disease severity
Read full study

CLINICAL STUDY #5

"The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems"

Published: 2015

Study Type: review article
Related Omni-Biotic Formulation: Stress Release

This review summarizes the available evidence describing the bi-directional gut-brain relationship including neural, endocrine, immune, and humoral pathways. It also explores relevant pathophysiological mechanisms.

Read full study

CLINICAL STUDY #6

"Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome"

Published: 2015

Study Type: review article
Related Omni-Biotic Formulation: Stress Release

This review highlights the evidence supporting the connection between stress and the gut microbiota, with specific focus on the mechanisms by which the microbiota impacts stress response, behavior, and visceral pain.

Read full study

Omni-Biotic Balance

CLINICAL STUDY #1

"Homeostatic Immunity and the Microbiota"

Published: 2017

Study Type: review article
Related Omni-Biotic Formulation: Balance

This review explores the roles the microbiome plays in the development and function of the immune system.

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CLINICAL STUDY #2

"Role of the Microbiota in Immunity and Inflammation"

Published: 2014

Study Type: review article
Related Omni-Biotic Formulation: Balance

This review discusses the relationship between the gut microbiome and immunity highlighting the influence of modern diet, pharmaceuticals and hygiene on rising rates of inflammatory and autoimmune disorders.

Read full study

CLINICAL STUDY #1

"Homeostatic Immunity and the Microbiota"

Published: 2017

Study Type: review article
Related Omni-Biotic Formulation: Balance

This review explores the roles the microbiome plays in the development and function of the immune system.

Read full study

CLINICAL STUDY #2

"Role of the Microbiota in Immunity and Inflammation"

Published: 2014

Study Type: review article
Related Omni-Biotic Formulation: Balance

This review discusses the relationship between the gut microbiome and immunity highlighting the influence of modern diet, pharmaceuticals and hygiene on rising rates of inflammatory and autoimmune disorders.

Read full study

Omni-Biotic Hetox

CLINICAL STUDY #1

"Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis"

Published: 2016

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Increased neutrophil resting burst and neopterin levels 
  • Improvement in liver function
  • Demonstrated safety and efficacy in stable liver cirrhosis
Read full study

CLINICAL STUDY #2

"Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial"

Published: 2017

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Reduced abdominal adiposity (hip:waist ratio)
  • Improved HOMA-IR
  • Demonstrated safety and efficacy in medication naive T2DM
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CLINICAL STUDY #3

"Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial"

Published: 2018

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Reduced circulating endotoxin levels (70%)
  • Reduced metabolic markers: glucose (38%), insulin (38%), HOMA-IR (64%), triglycerides (48%), total cholesterol (19%), total/HDL-cholesterol ratio (19%)
  • Reduced inflammatory markers: TNF-α (67%), IL-6 (77%), CRP (53%), resistin (53%)
Read full study

CLINICAL STUDY #4

"The gut-liver axis and the intersection with the microbiome"

Published: 2018

Study Type: review article
Related Omni-Biotic Formulation: Hetox

This review discusses gut-liver communications in various forms of liver disease and the potential to use the microbiome to determine the stage of liver disease as well as predicting the effects of dietary and pharmaceutical interventions.

Read full study

CLINICAL STUDY #1

"Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis"

Published: 2016

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Increased neutrophil resting burst and neopterin levels 
  • Improvement in liver function
  • Demonstrated safety and efficacy in stable liver cirrhosis
Read full study

CLINICAL STUDY #2

"Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial"

Published: 2017

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Reduced abdominal adiposity (hip:waist ratio)
  • Improved HOMA-IR
  • Demonstrated safety and efficacy in medication naive T2DM
Read full study

CLINICAL STUDY #3

"Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial"

Published: 2018

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Reduced circulating endotoxin levels (70%)
  • Reduced metabolic markers: glucose (38%), insulin (38%), HOMA-IR (64%), triglycerides (48%), total cholesterol (19%), total/HDL-cholesterol ratio (19%)
  • Reduced inflammatory markers: TNF-α (67%), IL-6 (77%), CRP (53%), resistin (53%)
Read full study

CLINICAL STUDY #4

"The gut-liver axis and the intersection with the microbiome"

Published: 2018

Study Type: review article
Related Omni-Biotic Formulation: Hetox

This review discusses gut-liver communications in various forms of liver disease and the potential to use the microbiome to determine the stage of liver disease as well as predicting the effects of dietary and pharmaceutical interventions.

Read full study

Omni-Biotic Panda

CLINICAL STUDY #1

"Identification of Strong Interleukin-10 Inducing Lactic Acid Bacteria which Down-Regulate T Helper Type 2 Cytokines"

Published: 2005

Study Type: preclinical analysis
Related Omni-Biotic Formulation: PandA

  • Decreased Th2 cytokine production
  • Diversion of immune system into regulatory/tolerant mode
Read full study

CLINICAL STUDY #2

"Selection of Probiotic Bacteria for Prevention of Allergic Diseases: Immunomodulation of Neonatal Dendritic Cells"

Published: 2007

Study Type: preclinical analysis
Related Omni-Biotic Formulation: PandA

  • Skewed neonatal naive T Cells toward Th1
  • Up-regulation of co-stimulatory molecules
  • No skewing toward Th2
Read full study

CLINICAL STUDY #3

"The Effects of Selected Probiotic Strains on the Development of Eczema (the PandA study)"

Published: 2009

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: PandA

  • Decreased in vitro production of IL-5
  • Increased Lc. lactis colonization
  • Reduced incidence of eczema in high-risk children
Read full study

CLINICAL STUDY #4

"Probiotic Supplementation Influences Faecal Short Chain Fatty Acids in Infants at High Rick for Eczema"

Published: 2015

Study Type: double blind, randomized controlled trial: follow-on
Related Omni-Biotic Formulation: PandA

  • Increased short chain fatty acid and lactate production
  • Decreased lactose and succinate levels
  • Demonatrated safety and efficacy in children at risk to develop eczema
Read full study

CLINICAL STUDY #5

"Probiotics and Primary Prevention of Atopic Dermatitis: A Meta-Analysis of Randomized Controlled Studies"

Published: 2014

Study Type: review article
Related Omni-Biotic Formulation: PandA

This meta analysis found that probiotics have a protective role in atopic dermatitis (eczema) prevention when administered during the pre- and post-natal period.

Read full study

CLINICAL STUDY #1

"Identification of Strong Interleukin-10 Inducing Lactic Acid Bacteria which Down-Regulate T Helper Type 2 Cytokines"

Published: 2005

Study Type: preclinical analysis
Related Omni-Biotic Formulation: PandA

  • Decreased Th2 cytokine production
  • Diversion of immune system into regulatory/tolerant mode
Read full study

CLINICAL STUDY #2

"Selection of Probiotic Bacteria for Prevention of Allergic Diseases: Immunomodulation of Neonatal Dendritic Cells"

Published: 2007

Study Type: preclinical analysis
Related Omni-Biotic Formulation: PandA

  • Skewed neonatal naive T Cells toward Th1
  • Up-regulation of co-stimulatory molecules
  • No skewing toward Th2
Read full study

CLINICAL STUDY #3

"The Effects of Selected Probiotic Strains on the Development of Eczema (the PandA study)"

Published: 2009

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: PandA

  • Decreased in vitro production of IL-5
  • Increased Lc. lactis colonization
  • Reduced incidence of eczema in high-risk children
Read full study

CLINICAL STUDY #4

"Probiotic Supplementation Influences Faecal Short Chain Fatty Acids in Infants at High Rick for Eczema"

Published: 2015

Study Type: double blind, randomized controlled trial: follow-on
Related Omni-Biotic Formulation: PandA

  • Increased short chain fatty acid and lactate production
  • Decreased lactose and succinate levels
  • Demonatrated safety and efficacy in children at risk to develop eczema
Read full study

CLINICAL STUDY #5

"Probiotics and Primary Prevention of Atopic Dermatitis: A Meta-Analysis of Randomized Controlled Studies"

Published: 2014

Study Type: review article
Related Omni-Biotic Formulation: PandA

This meta analysis found that probiotics have a protective role in atopic dermatitis (eczema) prevention when administered during the pre- and post-natal period.

Read full study