Microbiome | Immune Development and Omni-Biotic PandA Publications

Illustration of the maternal-neonatal-infant microbiota highlighting health and development

Shifts in the maternal microbiome and immune function occur naturally during the course of pregnancy. However these changes can negatively impact fetal immune and microbiome development. This in turn can increase the potential risk of allergic and autoimmune conditions in later life.

Clinical studies have demonstrated the immune development and microbiome balancing power of OMNi-BiOTiC® PandA with outcomes including reduced risk of infant/childhood allergic and atopic disease (i.e. eczema), reduced colic, and improved maternal gut function and comfort.

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Human Clinical Trials on Final Omni-Biotic Formulation

The following studies were performed on the commercial Omni-Biotic formulation available in the US market. In some cases the brand name will differ based on the European marketed product, but probiotic strains and formulation are identical.

The Effects of Selected Probiotic Strains on the Development of Eczema (the PandA study)
Author/Year: 2009; Niers, et al
Publication Type: Randomized Controlled Trial (RCT)
Key findings include:
  • Significantly lower incidence of infant eczema
  • Decreased IL-5 production
  • Increased Lc. lactis colonization
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Probiotic Supplementation Influences Faecal Short Chain Fatty Acids in Infants at High Rick for Eczema
Author/Year: Kim, et al.; 2015
Study Type: Randomized Controlled Trial (RCT)-follow on
Key findings include:
  • Increased short chain fatty acid and lactate production
  • Decreased lactose and succinate levels
  • Demonstrated safety and efficacy in children at risk to develop eczema
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Preclinical Trials

The following studies were performed on either the constituent ingredients or the final Omni-Biotic formulation available in the US market.

Selection of Probiotic Bacteria for Prevention of Allergic Diseases: Immunomodulation of Neonatal Dendritic Cells
Author/Year: Niers, et al.; 2007
Study Type: Preclinical
Key findings include:
  • Skewed neonatal naive T Cells toward Th1
  • Up-regulation of co-stimulatory molecules
  • No skewing toward Th2
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Reviews

The following papers are not specific to Omni-Biotic products but are provided here for informational and educational purposes.

Probiotics and Primary Prevention of Atopic Dermatitis: A Meta-Analysis of Randomized Controlled Studies
Year Published: 2015
Study Type: Review

This review of 26 studies indicates that probiotics seem to have a protective role in AD prevention if administered in the pre and postnatal period in both general and allergic risk populations.
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